Physiological properties of ascending locus coeruleus axons in the squirrel monkey

M. Segal, S. L. Foote, G. Aston-Jones

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Discharge activity was recorded extracellularly from individual neurons of the nucleus locus coeruleus in anesthetized squirrel monkeys. These cells exhibited long-duration (2-3 ms) action potentials and discharged spontaneously in a slow (0.2-2 Hz) irregular fashion. Stimulation of the lateral hypothalamus evoked antidromic responses at latencies of 10-20 ms, indicating conduction velocities of over 1 m/s in some cases. The mean refractory period for these axons was 2.6 ms. When the rate of hypothalamic stimulation was increased from 1 to 10 Hz there was a 15-20% increase in antidromic latencies. These properties are similar to those previously observed for rat LC neurons, except that conduction velocities are higher in monkey.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalBrain research
Issue number2
StatePublished - Sep 12 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • antidromic activation
  • impulse conduction
  • locus coeruleus
  • norepinephrine

Fingerprint Dive into the research topics of 'Physiological properties of ascending locus coeruleus axons in the squirrel monkey'. Together they form a unique fingerprint.

Cite this