Physiological properties of ascending locus coeruleus axons in the squirrel monkey

M. Segal; S. L. Foote; G. Aston-Jones

doi:10.1016/0006-8993(83)90723-0

Physiological properties of ascending locus coeruleus axons in the squirrel monkey

M. Segal, S. L. Foote, G. Aston-Jones

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Discharge activity was recorded extracellularly from individual neurons of the nucleus locus coeruleus in anesthetized squirrel monkeys. These cells exhibited long-duration (2-3 ms) action potentials and discharged spontaneously in a slow (0.2-2 Hz) irregular fashion. Stimulation of the lateral hypothalamus evoked antidromic responses at latencies of 10-20 ms, indicating conduction velocities of over 1 m/s in some cases. The mean refractory period for these axons was 2.6 ms. When the rate of hypothalamic stimulation was increased from 1 to 10 Hz there was a 15-20% increase in antidromic latencies. These properties are similar to those previously observed for rat LC neurons, except that conduction velocities are higher in monkey.

Original language	English (US)
Pages (from-to)	381-387
Number of pages	7
Journal	Brain research
Volume	274
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90723-0
State	Published - Sep 12 1983
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

antidromic activation
impulse conduction
locus coeruleus
norepinephrine

Access to Document

10.1016/0006-8993(83)90723-0

Fingerprint Dive into the research topics of 'Physiological properties of ascending locus coeruleus axons in the squirrel monkey'. Together they form a unique fingerprint.

Cite this

@article{70465b6967de4443bdc06e271efd422a,

title = "Physiological properties of ascending locus coeruleus axons in the squirrel monkey",

abstract = "Discharge activity was recorded extracellularly from individual neurons of the nucleus locus coeruleus in anesthetized squirrel monkeys. These cells exhibited long-duration (2-3 ms) action potentials and discharged spontaneously in a slow (0.2-2 Hz) irregular fashion. Stimulation of the lateral hypothalamus evoked antidromic responses at latencies of 10-20 ms, indicating conduction velocities of over 1 m/s in some cases. The mean refractory period for these axons was 2.6 ms. When the rate of hypothalamic stimulation was increased from 1 to 10 Hz there was a 15-20% increase in antidromic latencies. These properties are similar to those previously observed for rat LC neurons, except that conduction velocities are higher in monkey.",

keywords = "antidromic activation, impulse conduction, locus coeruleus, norepinephrine",

author = "M. Segal and Foote, {S. L.} and G. Aston-Jones",

note = "Funding Information: This work was supported by USPHS Grants NS-16209, NS-18023 and AA-03504. Dr. Floyd Bloom provided essential encouragement and facilities for these experiments.",

year = "1983",

month = sep,

day = "12",

doi = "10.1016/0006-8993(83)90723-0",

language = "English (US)",

volume = "274",

pages = "381--387",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Physiological properties of ascending locus coeruleus axons in the squirrel monkey

AU - Segal, M.

AU - Foote, S. L.

AU - Aston-Jones, G.

N1 - Funding Information: This work was supported by USPHS Grants NS-16209, NS-18023 and AA-03504. Dr. Floyd Bloom provided essential encouragement and facilities for these experiments.

PY - 1983/9/12

Y1 - 1983/9/12

N2 - Discharge activity was recorded extracellularly from individual neurons of the nucleus locus coeruleus in anesthetized squirrel monkeys. These cells exhibited long-duration (2-3 ms) action potentials and discharged spontaneously in a slow (0.2-2 Hz) irregular fashion. Stimulation of the lateral hypothalamus evoked antidromic responses at latencies of 10-20 ms, indicating conduction velocities of over 1 m/s in some cases. The mean refractory period for these axons was 2.6 ms. When the rate of hypothalamic stimulation was increased from 1 to 10 Hz there was a 15-20% increase in antidromic latencies. These properties are similar to those previously observed for rat LC neurons, except that conduction velocities are higher in monkey.

AB - Discharge activity was recorded extracellularly from individual neurons of the nucleus locus coeruleus in anesthetized squirrel monkeys. These cells exhibited long-duration (2-3 ms) action potentials and discharged spontaneously in a slow (0.2-2 Hz) irregular fashion. Stimulation of the lateral hypothalamus evoked antidromic responses at latencies of 10-20 ms, indicating conduction velocities of over 1 m/s in some cases. The mean refractory period for these axons was 2.6 ms. When the rate of hypothalamic stimulation was increased from 1 to 10 Hz there was a 15-20% increase in antidromic latencies. These properties are similar to those previously observed for rat LC neurons, except that conduction velocities are higher in monkey.

KW - antidromic activation

KW - impulse conduction

KW - locus coeruleus

KW - norepinephrine

UR - http://www.scopus.com/inward/record.url?scp=0021101790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021101790&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(83)90723-0

DO - 10.1016/0006-8993(83)90723-0

M3 - Article

C2 - 6626968

AN - SCOPUS:0021101790

VL - 274

SP - 381

EP - 387

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Physiological properties of ascending locus coeruleus axons in the squirrel monkey

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Cite this