Physiological systems modeling, simulation, and control

Physiological systems modeling, simulation, and control is a research area integrating science and engineering and contributes to a continuous refinement of knowledge on how the body works. The roots of modeling a body area date back thousands of years, yet it was not until the 1950s that the tree of knowledge started to be fed with data-driven hypotheses and interventions. This chapter tries to organize disparate information of the most important modeling, simulation, and control perspectives into a coherent set of views currently applied to modern biological and medical research. It is addressed to researchers on human system physiological modeling, working both in academia and in industry to address current and future research goals.