Phytoestrogen consumption and endometrial cancer risk: A population-based case-control study in New Jersey

Elisa V. Bandera, Melony G. Williams, Camelia Sima, Sharon Bayuga, Katherine Pulick, Homer Wilcox, Robert Soslow, Ann G. Zauber, Sara H. Olson

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Phytoestrogens have been shown to exert anti-estrogenic and estrogenic effects in some tissues, including the breast. However, only a few studies have evaluated their role in endometrial cancer risk. We evaluated this association in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed an interview, including a food frequency questionnaire with supplemental questions for phytoestrogen foods. Risk estimates were derived using an unconditional logistic regression, adjusting for major risk factors for endometrial cancer. There was some suggestion of a decreased risk with quercetin intake (OR: 0.65; 95% CI: 0.41-1.01 for the highest compared to the lowest quartile; p for trend: 0.02). We found a limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens. However, there was some suggestion of an inverse association with total isoflavone intake limited to lean women (BMI <25; OR for the highest tertile: 0.50; 95% CI: 0.25-0.98) and those with a waist-to-hip ratio ≤0.85 (OR: 0.59; 95% CI: 0.33-1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women.

Original languageEnglish (US)
Pages (from-to)1117-1127
Number of pages11
JournalCancer Causes and Control
Volume20
Issue number7
DOIs
StatePublished - Sep 1 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Diet
  • Endometrial neoplasms
  • Isoflavones
  • Lignans
  • Phytoestrogens
  • Quercetin

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    Bandera, E. V., Williams, M. G., Sima, C., Bayuga, S., Pulick, K., Wilcox, H., Soslow, R., Zauber, A. G., & Olson, S. H. (2009). Phytoestrogen consumption and endometrial cancer risk: A population-based case-control study in New Jersey. Cancer Causes and Control, 20(7), 1117-1127. https://doi.org/10.1007/s10552-009-9336-9