Pituitary Hypoplasia

Mariam Gangat; Sally Radovick

doi:10.1016/j.ecl.2017.01.003

Pituitary Hypoplasia

Mariam Gangat, Sally Radovick

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

This article summarizes pituitary development and function as well as specific mutations of genes encoding the following transcription factors: HESX1, LHX3, LHX4, POU1F1, PROP1, and OTX2. Although several additional genetic defects related to hypopituitarism have been identified, this article focuses on these selected factors, as they have been well described in the literature in terms of clinical characterization of affected patients and molecular mechanisms of action, and therefore, are very relevant to clinical practice.

Original language	English (US)
Pages (from-to)	247-257
Number of pages	11
Journal	Endocrinology and Metabolism Clinics of North America
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2017.01.003
State	Published - Jun 2017

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

Combined pituitary hormone deficiency
Hypopituitarism
Pituitary development
Transcription factor

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10.1016/j.ecl.2017.01.003

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title = "Pituitary Hypoplasia",

abstract = "This article summarizes pituitary development and function as well as specific mutations of genes encoding the following transcription factors: HESX1, LHX3, LHX4, POU1F1, PROP1, and OTX2. Although several additional genetic defects related to hypopituitarism have been identified, this article focuses on these selected factors, as they have been well described in the literature in terms of clinical characterization of affected patients and molecular mechanisms of action, and therefore, are very relevant to clinical practice.",

keywords = "Combined pituitary hormone deficiency, Hypopituitarism, Pituitary development, Transcription factor",

author = "Mariam Gangat and Sally Radovick",

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year = "2017",

month = jun,

doi = "10.1016/j.ecl.2017.01.003",

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AU - Gangat, Mariam

AU - Radovick, Sally

PY - 2017/6

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AB - This article summarizes pituitary development and function as well as specific mutations of genes encoding the following transcription factors: HESX1, LHX3, LHX4, POU1F1, PROP1, and OTX2. Although several additional genetic defects related to hypopituitarism have been identified, this article focuses on these selected factors, as they have been well described in the literature in terms of clinical characterization of affected patients and molecular mechanisms of action, and therefore, are very relevant to clinical practice.

KW - Combined pituitary hormone deficiency

KW - Hypopituitarism

KW - Pituitary development

KW - Transcription factor

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JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 2

ER -

Pituitary Hypoplasia

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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