Abstract
This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'Nested repeated confidence intervals and switching between noninferiority and superiority' by Joachim Hartung and Guido Knapp; 'Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and 'Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 656-659 |
| Number of pages | 4 |
| Journal | Biometrical Journal |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2006 |
All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Statistics, Probability and Uncertainty
Keywords
- Adaptive planning
- Adaptive seamless design
- Adaptive tests
- Closure principle
- Combination tests
- Early stopping
- Group sequential clinical trials
- Hypotheses selection
- Multiple testing
- Noninferiority
- Repeated confidence intervals
- Self-designing