Plant microtubule inhibitors against trypanosomatids

M. M. Chan, D. Fong

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Trypanosomatid protozoa are etiologic agents of several prevalent tropical diseases. Tubulins constitute 10% of the total proteins of these organisms. In addition, they are conserved within the Trypanosomatidae family but are different from that of the mammalian hosts. Since current chemotherapy has severe side effects, new compounds are urgently needed. The microtubular system provides a target for selective chemotherapy. Plant microtubule inhibitors, trifluralin and its analogues, inhibits Leishmania and Trypanosoma brucei, and Marion Chan and Dunne Fong here discuss the biosafety and potential for development of drug resistance to these compounds.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalParasitology Today
Volume10
Issue number11
DOIs
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Parasitology

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