Platelet receptor interactions with polymer-adsorbed ligands observed by a quartz crystal microbalance sensor

N. Weber, J. Kohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Selective adsorption of plasma adsorption proteins to different biomaterials and the subsequent binding of purified platelet receptor (GPIIb-IIa) in real time by using quartz crystal microbalance (QCM) sensors. A method aimed at online investigation of the receptor binding events to preadsorbed plasma proteins on polymeric surfaces was presented. Concentrations of surface-adsorbed fibronectin or fibrinogen on test polymers were found to correlate with the binding capacities of GPIIb-IIIa. The binding of GPII-IIIa to surface-adsorbed fibronectin/fibronogen was also found to be suppressed by blocking GPIIb-IIIa with synthetic inhibitor peptides (GRGDSP).

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1322
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period5/17/045/21/04

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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