Platelet sodium-hydrogen antiport in obese and diabetic black women

Zoltan Zentay, Alluru Reddi, Maya Raguwanshi, Jeffrey P. Gardner, Jwa Hwa Cho, Norman Lasker, Amita Dasmahapatra, Abraham Aviv

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In this investigation we correlated platelet Na-H antiport parameters with blood pressure and serum lipids in a sample population of non-insulin-dependent diabetic obese, nondiabetic obese, and nondiabetic nonobese black women. Parameters of the Na-H antiport were examined in aspirin-treated platelets. These parameters were not altered in resting or in thrombin-stimulated platelets of diabetic patients. The activity index of platelet Na-H antiport after thrombin stimulation was positively correlated with the blood pressure (systolic blood pressure, r=0.5320 and p=0.0001; diastolic blood pressure, r=0.5123 and P=0.0017). Lower high density lipoprotein cholesterol levels were associated with an alkaline shift in the cytosolic pH set point for activation of the Na-H antiport. Highly significant correlations were also observed between the total cholesterol/high density lipoprotein cholesterol ratio and the cytosolic pH set point for activation of the Na-H antiport. These correlations were independent of diabetes or the body mass index. Together, these observations indicate that parameters of platelet Na-H antiport are altered with an increase in blood pressure and a decrease in serum high density lipoprotein cholesterol.

Original languageEnglish (US)
Pages (from-to)549-554
Number of pages6
JournalHypertension
Volume20
Issue number4
StatePublished - Oct 1992

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Keywords

  • Diabetes mellitus, non-insulin-dependent
  • Hypertension, essential
  • Lipoproteins, HDL

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