Platelet Transfusion Therapy: One-Hour Posttransfusion Increments Are Valuable in Predicting the Need for HLA-Matched Preparations

Peter A. Daly, Charles A. Schiffer, Joseph Aisner, Peter H. Wiernik

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Seventy-nine platelet transfusions to 73 thrombocytopenic patients with cancer were analyzed to determine whether a platelet count obtained one hour after transfusion could help differentiate between alloimmunization and other clinical factors that result in rapid platelet destruction. These transfusions were selected because 18- to 24-hour increments were inadequate in response to fresh, random donor platelets. A corrected count increment (CI) (CI=[posttransfusion count—pretransfusion count]×body surface area [sq m]/platelets transfused×1011) at one hour of 10×103/μL or greater was associated with absence of lymphocytotoxic antibody, whereas increments of less than 10×103/μL were generally associated with high levels of strongly cytotoxic antibody. HLA-matched transfusions produced no improvement in increments when the previous one-hour CI had been 10×103/μL or greater, whereas in the other group significantly better increments were obtained. A one-hour posttransfusion count is a simple test that correlates well with the presence of antibody against HLA antigens, is valuable in predicting the need for HLA-matched platelets, and helps avoid wasteful, empirical use of such transfusions. (JAMA 243:435-438, 1980).

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume243
Issue number5
DOIs
StatePublished - Feb 1 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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