PML and the oncogenic nuclear domains in regulating transcriptional repression: Commentary

Hui Li, J. Don Chen

Research output: Contribution to journalComment/debate

21 Scopus citations

Abstract

Promyelocytic leukemia protein (PML) is a tumor suppressor involved in the t(15;17) translocation that causes acute promyelocytic leukemia (APL). PML is located at multiple nuclear domains known as PML oncogenic domains (PODs), whose structures are dynamically regulated and disrupted in t(15;17) APL cells. PML is involved in several important cellular processes; however, its exact function is unclear. Recently, a POD-associated protein was found to be transcriptional repressor, suggesting a new role for PODs in regulating transcriptional repression.

Original languageEnglish (US)
Pages (from-to)641-644
Number of pages4
JournalCurrent Opinion in Cell Biology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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