Point mutation rate of bacteriophage ΦX174

José M. Cuevas, Siobain Duffy, Rafael Sanjuán

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The point mutation rate of phage ΦX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0 x 10-6 substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying in DNA-based microorganisms).

Original languageEnglish (US)
Pages (from-to)747-749
Number of pages3
Issue number2
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Genetics

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