Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma

John Strasswimmer, Mark Pierce, B. Hyle Park, Victor Neel, Johannes F. De Boer

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Skin cancer is the most common human malignancy, with basal cell carcinoma (BCC) the most frequent type. Aggressive forms of BCC are associated with extensive dermal invasion and destruction of collagen. Surgery is the most common treatment, but identification of tumor borders is a challenge. Polarization-sensitive optical coherence tomography (PS-OCT) is an optical method to examine collagen birefringence. To date, it has not been exploited for cancer management. As part of a pilot exploratory study to examine the use of OCT in skin cancer, we examined several tumors that pose a challenge to the surgeon due to their large size and histological subtype. In normal perilesional skin, OCT identifies epidermal and dermal structure; PS-OCT identified dermal birefringence. In BCC, tumors lost normal structure and gained the appearance of lobular impressions. PS-OCT identified an alteration of dermal birefringence. Examination of a border area revealed a gradual transition from more normal appearing image to frank tumor. These results indicate that PS-OCT can identify features that distinguish normal skin from tumor and may have the potential to guide surgeons in the treatment of aggressive skin cancer.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
JournalJournal of Biomedical Optics
Volume9
Issue number2
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

Fingerprint

Optical tomography
Tumors
Skin
tomography
cancer
Cells
Polarization
Birefringence
tumors
polarization
Collagen
birefringence
surgeons
collagens
borders
Surgery
surgery
destruction
examination
optics

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Strasswimmer, John ; Pierce, Mark ; Park, B. Hyle ; Neel, Victor ; De Boer, Johannes F. / Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma. In: Journal of Biomedical Optics. 2004 ; Vol. 9, No. 2. pp. 292-298.
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Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma. / Strasswimmer, John; Pierce, Mark; Park, B. Hyle; Neel, Victor; De Boer, Johannes F.

In: Journal of Biomedical Optics, Vol. 9, No. 2, 01.03.2004, p. 292-298.

Research output: Contribution to journalArticle

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