Polyclonal polymorphic B‐cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome

Vijay V. Joshi, Shirley Kauffman, James Oleske, Senih Fikrig, Thomas Denny, Charles Gadol, Eun Lee

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Four cases of pediatric Acquired Immune Deficiency Syndrome (AIDS) with lymphoproliferative disorder are described and other lymphoid lesions in previously reported cases of pediatric AIDS are reviewed. The lymphoproliferative disorder was characterized by polyclonal, polymorphic B‐cell content without evidence of cellular atypia, necrosis or prominent mitotic activity but with predominantly extranodal systemic and prominent pulmonary involvement. Since the lesion has overlapping features it is considered to be intermediate between benign and malignant lymphoproliferations and designated as polyclonal, polymorphic B‐cell lymphoproliferative disorder (PBLD) of pediatric AIDS. The PBLD is part of a spectrum of lymphoid lesions in pediatric AIDS consisting of follicular lymphoid hyperplasia of nodal and extranodal sites, pulmonary lymphoid hyperplasia/lymphoid interstitial pneumonitis complex (PLH/LIP complex) in cases previously reported by the authors, and also malignant lymphoma reported by others. It is possible that Epstein‐Barr virus (EBV) by itself or in synergism with human T‐lymphotropic virus‐type III (HTLV‐III) is related to pathogenesis of PBLD in children with AIDS.

Original languageEnglish (US)
Pages (from-to)1455-1462
Number of pages8
JournalCancer
Volume59
Issue number8
DOIs
StatePublished - Jan 1 1987

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Lymphoproliferative Disorders
Acquired Immunodeficiency Syndrome
Lung
Pediatrics
Hyperplasia
Interstitial Lung Diseases
Lymphoma
Necrosis
Viruses

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Joshi, Vijay V. ; Kauffman, Shirley ; Oleske, James ; Fikrig, Senih ; Denny, Thomas ; Gadol, Charles ; Lee, Eun. / Polyclonal polymorphic B‐cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. In: Cancer. 1987 ; Vol. 59, No. 8. pp. 1455-1462.
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Polyclonal polymorphic B‐cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. / Joshi, Vijay V.; Kauffman, Shirley; Oleske, James; Fikrig, Senih; Denny, Thomas; Gadol, Charles; Lee, Eun.

In: Cancer, Vol. 59, No. 8, 01.01.1987, p. 1455-1462.

Research output: Contribution to journalArticle

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AU - Kauffman, Shirley

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AU - Denny, Thomas

AU - Gadol, Charles

AU - Lee, Eun

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