Polycomb and Trithorax control genome expression by determining the alternative chromatin epigenetic states for key developmental regulators

Yu B. Schwartz, T. G. Kahn, V. Pirrotta

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genomic analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.

Original languageEnglish (US)
Pages (from-to)1247-1249
Number of pages3
JournalRussian Journal of Genetics
Volume46
Issue number10
DOIs
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Genetics

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