Polyethylene glycol-lysine copolymers. New biocompatible polymers for biomedical applications

Aruna Nathan, Samuel Zalipsky, Joachim Kohn

Research output: Contribution to journalConference article

15 Scopus citations

Abstract

Unique properties of polyethylene glycol (PEG) including wide range of solubilities, lack of toxicity, absence of antigenicity and immunogenicity, non-interference with enzymatic activities and conformations of polypeptides, non-biodegradability, and ease of excretion from living organisms, all suggest that this polymer may be an ideal drug carrier. We developed an efficient method for the synthesis of water soluble polyurethanes comprised of lysine and PEG units. The properties of the new polymers are dominated by PEG, while the carboxyl groups of the lysyl residues provide convenient anchors for attachment of the appropriate pendant ligands. The distance between the reactive carboxyl groups is controlled by the size of PEG-macromonomer, and the molecular weight of the PEG-lysine copolymer can be fine-tuned by a careful choice of polycondensation conditions.

Original languageEnglish (US)
Pages (from-to)213-214
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
Publication statusPublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

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