Polymorphism of nitric oxide synthase 1 affects the clinical phenotypes of ischemic stroke in Korean population

Seung Don Yoo, Jun Sang Park, Dong Hwan Yun, Hee Sang Kim, Su Kang Kim, Dong Hwan Kim, Jinmann Chon, Goun Je, Yoon Seong Kim, Joo Ho Chung, Seung Joon Chung, Jin Ah Yeo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective To investigate whether four single nucleotide polymorphisms (SNPs) rs2293054 [Ile734Ile], rs1047735 [His902His], rs2293044 [Val1353Val], rs2682826 (3'UTR) of nitric oxide synthase 1 (NOS1) are associated with the development and clinical phenotypes of ischemic stroke. Methods We enrolled 120 ischemic stroke patients and 314 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, <6 and >6) and Modified Barthel Index (MBI, <60 and >60). SNPStats, SNPAnalyzer, and HelixTree programs were used to calculate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Multiple logistic regression models were performed to analyze genetic data. Results No SNPs of the NOS1 gene were found to be associated with ischemic stroke. However, in an analysis of clinical phenotypes, we found that rs2293054 was associated with the NIHSS scores of ischemic stroke patients in codominant (p=0.019), dominant (p=0.007), overdominant (p=0.033), and log-additive (p=0.0048) models. Also, rs2682826 revealed a significant association in the recessive model (p=0.034). In allele frequency analysis, we also found that the T alleles of rs2293054 were associated with lower NIHSS scores (p=0.007). Respectively, rs2293054 had a significant association in the MBI scores of ischemic stroke in codominant (p=0.038), dominant (p=0.031), overdominant (p=0.045), and log-additive (p=0.04) models. Conclusion These results suggest that NOS1 may be related to the clinical phenotypes of ischemic stroke in Korean population.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalAnnals of Rehabilitation Medicine
Volume40
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rehabilitation

Keywords

  • Ischemic stroke
  • Modified barthel index
  • National institutes of health stroke survey
  • Nitric oxide synthase 1
  • Polymorphism

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