Polyunsaturated fatty acid regulation of gene expression

Harini Sampath, James M. Ntambi

Research output: Contribution to journalReview articlepeer-review

196 Scopus citations


Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalNutrition Reviews
Issue number9
StatePublished - Sep 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


  • HNF-4α
  • LXR α
  • PPAR-α
  • Polyunsaturated fatty acids
  • SREBP1c


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