Portopulmonary hypertension and the liver transplant candidate

Paul C. Kuo, Jeffrey S. Plotkin, Sean Gaine, Rebecca A. Schroeder, Vinod K. Rustgi, Lewis J. Rubin, Lynt B. Johnson

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention to avoid right ventricular failure from acutely elevated pulmonary artery pressures or sudden increases in right ventricular preload is a key physiologic tenet of management. With increased surgical expertise, anesthetic sophistication, and availability of epoprostenol, PPHTN is no longer considered an absolute contraindication for OLT.

Original languageEnglish (US)
Pages (from-to)1087-1093
Number of pages7
Issue number8
StatePublished - Apr 27 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Transplantation

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