Portopulmonary hypertension and the liver transplant candidate

Paul C. Kuo; Jeffrey S. Plotkin; Sean Gaine; Rebecca A. Schroeder; Vinod K. Rustgi; Lewis J. Rubin; Lynt B. Johnson

doi:10.1097/00007890-199904270-00001

Portopulmonary hypertension and the liver transplant candidate

Paul C. Kuo, Jeffrey S. Plotkin, Sean Gaine, Rebecca A. Schroeder, Vinod K. Rustgi, Lewis J. Rubin, Lynt B. Johnson

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention to avoid right ventricular failure from acutely elevated pulmonary artery pressures or sudden increases in right ventricular preload is a key physiologic tenet of management. With increased surgical expertise, anesthetic sophistication, and availability of epoprostenol, PPHTN is no longer considered an absolute contraindication for OLT.

Original language	English (US)
Pages (from-to)	1087-1093
Number of pages	7
Journal	Transplantation
Volume	67
Issue number	8
DOIs	https://doi.org/10.1097/00007890-199904270-00001
State	Published - Apr 27 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Transplantation

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abstract = "The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention to avoid right ventricular failure from acutely elevated pulmonary artery pressures or sudden increases in right ventricular preload is a key physiologic tenet of management. With increased surgical expertise, anesthetic sophistication, and availability of epoprostenol, PPHTN is no longer considered an absolute contraindication for OLT.",

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AU - Gaine, Sean

AU - Schroeder, Rebecca A.

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AU - Rubin, Lewis J.

AU - Johnson, Lynt B.

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AB - The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention to avoid right ventricular failure from acutely elevated pulmonary artery pressures or sudden increases in right ventricular preload is a key physiologic tenet of management. With increased surgical expertise, anesthetic sophistication, and availability of epoprostenol, PPHTN is no longer considered an absolute contraindication for OLT.

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Portopulmonary hypertension and the liver transplant candidate

Abstract

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