Post-hematopoietic stem cell transplant immunization practices in the pediatric blood and marrow transplant consortium

Michelle P. Hudspeth, Tamara N. Hill, Jocelyn A. Lewis, Emily Van Meter, Dominic Ragucci

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background. A survey of National Marrow Donor Program transplant centers in 1995 demonstrated a wide range of immunization practices in post-hematopoietic stem cell transplant (HSCT) recipients, which led to the 2000 Centers for Disease Control and Prevention (CDC) recommendations for vaccination after HSCT. We surveyed the principal investigators of the Pediatric Blood and Marrow Transplant Consortium (PBMTC) to identify immunization practice patterns after HSCT and assess compliance with the 2000 CDC guidelines. Procedure. Approval was obtained from the Medical University of South Carolina Institutional Review Board. A 33 question survey using was distributed by email to principal investigators in the PBMTC. Results. Forty-one (40%) of the 102 pediatric HSCT centers participating in the PBMTC responded. Thirty of the responding centers completed the entire survey. For individual vaccines, compliance with the CDC guidelines ranged from 22% to 93%. Less than 20% of the centers reported schedules consistent with the 2000 CDC recommendations for both allogeneic and autologous HSCT recipients. Conclusion. Despite the 2000 CDC guidelines, wide variation in post-HSCT immunization practices still exists. Updated guidelines have been needed, particularly to address the use of the pneumococcal conjugate vaccine. In conjunction with multiple other groups, the CDC recently released new immunization guidelines in October 2009. Additional data are still needed to adequately address the utility of incorporating immunologic parameters with the timing of vaccination after HSCT.

Original languageEnglish (US)
Pages (from-to)970-975
Number of pages6
JournalPediatric Blood and Cancer
Issue number7
StatePublished - Jul 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


  • Hematopoietic stem cell transplant
  • Immunizations
  • Pediatric


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