Posttraumatic syrinx formation: Experimental study

W. A. Cohen, W. Young, V. DeCrescito, S. Horii, I. I. Kricheff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


An experimental study was performed to examine posttraumatic spinal cord cavitation in an animal model by evaluating immediate and delayed computed tomographic (CT) scans obtained after administration of intrathecal contrast material. Four cats underwent midthoracic laminectomy and spinal cord contusion using a standard 400 g-cm model. All animals were studied by CT with intrathecal contrast enhancement before and 4-5 days, 3-4 weeks, and 7-13 weeks after experimental cord contusion. Either metrizamide or iopamidol was used as the contrast agent. Two of the four cats had CT and pathologic evidence of cord cavitation at the site of injury. Another animal had uptake of contrast material into the spinal cord without pathologic evidence of cyst formation, which was believed to represent malacic change. The fourth animal had a normal-appearing cord by both CT and pathologic criteria. Animals that received metrizamide after cord contusion had generalized myoclonic seizures. This did not occur when iopamidol was administered.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number5
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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