Prediction and design of outer membrane protein-protein interactions

Vikas Nanda, Daniel Hsieh, Alexander Davis

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Protein-protein interactions (PPI) play central roles in biological processes, motivating us to understand the structural basis underlying affinity and specificity. In this chapter, we focus on biochemical and computational design strategies of assessing and detecting PPIs of β-barrel outer membrane proteins (OMPs). A few case studies are presented highlighting biochemical techniques used to dissect the energetics of oligomerization and determine amino acids forming the key interactions of the PPI sites. Current computational strategies for detecting/predicting PPIs are introduced, and examples of computational and rational engineering strategies applied to OMPs are presented.

Original languageEnglish (US)
Title of host publicationMembrane Proteins
Subtitle of host publicationFolding, Association, and Design
EditorsGiovanna Ghirlanda, Alessandro Senes
Pages183-196
Number of pages14
DOIs
StatePublished - Sep 20 2013

Publication series

NameMethods in Molecular Biology
Volume1063
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Keywords

  • Computational design
  • Outer membrane proteins
  • Protein-protein interactions

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