Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population

Juan L. Molina, Gabriela González Alemán, Ncrossed Florenzano, Eduardo Padilla, María Calvó, Gonzalo Guerrero, Danielle Kamis, Lee Stratton, Juan Toranzo, Beatriz Molina Rangeon, Helena Hernández Cuervo, Mercedes Bourdieu, Manuel Sedó, Sergio Strejilevich, Claude Robert Cloninger, Javier Escobar, Gabriel A. De Erausquin

Research output: Contribution to journalArticle

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Abstract

Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied. Aims: To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls. Method: Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound. Results: Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls. Conclusions: PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.

Original languageEnglish (US)
Pages (from-to)1486-1495
Number of pages10
JournalSchizophrenia bulletin
Volume42
Issue number6
DOIs
StatePublished - Nov 1 2016

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Keywords

  • endophenotype
  • genetic risk
  • literacy-independent neuropsychological testing indigenous populations
  • parkinsonism
  • schizotaxia
  • transcranial ultrasound

Cite this

Molina, J. L., González Alemán, G., Florenzano, N., Padilla, E., Calvó, M., Guerrero, G., Kamis, D., Stratton, L., Toranzo, J., Molina Rangeon, B., Hernández Cuervo, H., Bourdieu, M., Sedó, M., Strejilevich, S., Cloninger, C. R., Escobar, J., & De Erausquin, G. A. (2016). Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population. Schizophrenia bulletin, 42(6), 1486-1495. https://doi.org/10.1093/schbul/sbw023