Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population

Juan L. Molina, Gabriela González Alemán, Ncrossed Florenzano, Eduardo Padilla, María Calvó, Gonzalo Guerrero, Danielle Kamis, Lee Stratton, Juan Toranzo, Beatriz Molina Rangeon, Helena Hernández Cuervo, Mercedes Bourdieu, Manuel Sedó, Sergio Strejilevich, Claude Robert Cloninger, Javier Escobar, Gabriel A. De Erausquin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied. Aims: To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls. Method: Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound. Results: Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls. Conclusions: PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.

Original languageEnglish (US)
Pages (from-to)1486-1495
Number of pages10
JournalSchizophrenia bulletin
Volume42
Issue number6
DOIs
StatePublished - Nov 1 2016

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Population Groups
Antipsychotic Agents
Schizophrenia
Mesencephalon
Endophenotypes
Executive Function
Intelligence
Cognition
Hand

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Keywords

  • endophenotype
  • genetic risk
  • literacy-independent neuropsychological testing indigenous populations
  • parkinsonism
  • schizotaxia
  • transcranial ultrasound

Cite this

Molina, Juan L. ; González Alemán, Gabriela ; Florenzano, Ncrossed ; Padilla, Eduardo ; Calvó, María ; Guerrero, Gonzalo ; Kamis, Danielle ; Stratton, Lee ; Toranzo, Juan ; Molina Rangeon, Beatriz ; Hernández Cuervo, Helena ; Bourdieu, Mercedes ; Sedó, Manuel ; Strejilevich, Sergio ; Cloninger, Claude Robert ; Escobar, Javier ; De Erausquin, Gabriel A. / Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia : A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population. In: Schizophrenia bulletin. 2016 ; Vol. 42, No. 6. pp. 1486-1495.
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abstract = "Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied. Aims: To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls. Method: Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound. Results: Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls. Conclusions: PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.",
keywords = "endophenotype, genetic risk, literacy-independent neuropsychological testing indigenous populations, parkinsonism, schizotaxia, transcranial ultrasound",
author = "Molina, {Juan L.} and {Gonz{\'a}lez Alem{\'a}n}, Gabriela and Ncrossed Florenzano and Eduardo Padilla and Mar{\'i}a Calv{\'o} and Gonzalo Guerrero and Danielle Kamis and Lee Stratton and Juan Toranzo and {Molina Rangeon}, Beatriz and {Hern{\'a}ndez Cuervo}, Helena and Mercedes Bourdieu and Manuel Sed{\'o} and Sergio Strejilevich and Cloninger, {Claude Robert} and Javier Escobar and {De Erausquin}, {Gabriel A.}",
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Molina, JL, González Alemán, G, Florenzano, N, Padilla, E, Calvó, M, Guerrero, G, Kamis, D, Stratton, L, Toranzo, J, Molina Rangeon, B, Hernández Cuervo, H, Bourdieu, M, Sedó, M, Strejilevich, S, Cloninger, CR, Escobar, J & De Erausquin, GA 2016, 'Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population', Schizophrenia bulletin, vol. 42, no. 6, pp. 1486-1495. https://doi.org/10.1093/schbul/sbw023

Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia : A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population. / Molina, Juan L.; González Alemán, Gabriela; Florenzano, Ncrossed; Padilla, Eduardo; Calvó, María; Guerrero, Gonzalo; Kamis, Danielle; Stratton, Lee; Toranzo, Juan; Molina Rangeon, Beatriz; Hernández Cuervo, Helena; Bourdieu, Mercedes; Sedó, Manuel; Strejilevich, Sergio; Cloninger, Claude Robert; Escobar, Javier; De Erausquin, Gabriel A.

In: Schizophrenia bulletin, Vol. 42, No. 6, 01.11.2016, p. 1486-1495.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia

T2 - A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls from an Indigenous Population

AU - Molina, Juan L.

AU - González Alemán, Gabriela

AU - Florenzano, Ncrossed

AU - Padilla, Eduardo

AU - Calvó, María

AU - Guerrero, Gonzalo

AU - Kamis, Danielle

AU - Stratton, Lee

AU - Toranzo, Juan

AU - Molina Rangeon, Beatriz

AU - Hernández Cuervo, Helena

AU - Bourdieu, Mercedes

AU - Sedó, Manuel

AU - Strejilevich, Sergio

AU - Cloninger, Claude Robert

AU - Escobar, Javier

AU - De Erausquin, Gabriel A.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied. Aims: To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls. Method: Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound. Results: Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls. Conclusions: PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.

AB - Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives. Also, multiple reports reveal parkisonian motor deficits in untreated subjects with schizophrenia and in first-degree relatives of affected subjects. Yet, the relation between motor and cognitive impairment and its value as a classifier of endophenotypes has not been studied. Aims: To test the efficacy of midbrain hyperechogenicity (MHE) and parkinsonian motor impairment (PKM) as predictors of neurocognitive impairment in subjects with or at risk for schizophrenia, that could be used to segregate them from first-degree relatives and healthy controls. Method: Seventy-six subjects with chronic schizophrenia never exposed to antipsychotic medication, 106 unaffected first-degree relatives, and 62 healthy controls were blindly assessed for cognitive and motor function, and transcranial ultrasound. Results: Executive function, fluid intelligence, motor planning, and hand coordination showed group differences. PKM and MHE were significantly higher in untreated schizophrenia and unaffected relatives. Unaffected relatives showed milder impairment, but were different from controls. Conclusions: PKM and MHE predict cognitive impairment in neuroleptic-naive patients with schizophrenia and their unaffected first-degree relatives and may be used to segregate them from first-degree relatives and healthy controls.

KW - endophenotype

KW - genetic risk

KW - literacy-independent neuropsychological testing indigenous populations

KW - parkinsonism

KW - schizotaxia

KW - transcranial ultrasound

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U2 - 10.1093/schbul/sbw023

DO - 10.1093/schbul/sbw023

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VL - 42

SP - 1486

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JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

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