TY - JOUR
T1 - Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice
AU - Xiao, Shuo
AU - Diao, Honglu
AU - Smith, Mary Alice
AU - Song, Xiao
AU - Ye, Xiaoqin
N1 - Funding Information:
The experimental design, data collection, analysis and interpretation for this study and the writing of this report were supported by the Office of the Vice President for Research, Interdisciplinary Toxicology Program, and Department of Physiology and Pharmacology at University of Georgia; and NIH R15HD066301.
Funding Information:
The authors thank Dr. Zhen Fu at Department of Pathology, University of Georgia, for the access to the imaging system; Dr. Michael K. Skinner at Washington State University and Dr. John J. Wagner at University of Georgia, for insightful comments on the discussion; Ms. Kali King at Department of Physiology and Pharmacology, University of Georgia, for English editing; the Office of the Vice President for Research, Interdisciplinary Toxicology Program , and Department of Physiology and Pharmacology at University of Georgia , and National Institutes of Health (NIH R15HD066301 to X.Y.) for financial support.
PY - 2011/12
Y1 - 2011/12
N2 - To investigate the effects of bisphenol A (BPA) on embryo and uterine factors in embryo implantation, timed pregnant C57BL6 females were treated subcutaneously with 0, 0.025, 0.5, 10, 40, and 100. mg/kg/day BPA from gestation days 0.5-3.5. In 100. mg/kg/day BPA-treated females, no implantation sites were detected on day 4.5 but retention of embryos in the oviduct and delayed embryo development were detected on day 3.5. When untreated healthy embryos were transferred to pseudopregnant females treated with 100. mg/kg/day BPA, no implantation sites were detected on day 4.5. In 40. mg/kg/day BPA-treated females, delayed implantation and increased perinatal lethality of their offspring were observed. Implantation seemed normal in the rest BPA-treated groups or the female offspring from 40. mg/kg/day BPA-treated group. These data demonstrate the adverse effects of high doses of BPA on processes critical for embryo implantation: embryo transport, preimplantation embryo development, and establishment of uterine receptivity.
AB - To investigate the effects of bisphenol A (BPA) on embryo and uterine factors in embryo implantation, timed pregnant C57BL6 females were treated subcutaneously with 0, 0.025, 0.5, 10, 40, and 100. mg/kg/day BPA from gestation days 0.5-3.5. In 100. mg/kg/day BPA-treated females, no implantation sites were detected on day 4.5 but retention of embryos in the oviduct and delayed embryo development were detected on day 3.5. When untreated healthy embryos were transferred to pseudopregnant females treated with 100. mg/kg/day BPA, no implantation sites were detected on day 4.5. In 40. mg/kg/day BPA-treated females, delayed implantation and increased perinatal lethality of their offspring were observed. Implantation seemed normal in the rest BPA-treated groups or the female offspring from 40. mg/kg/day BPA-treated group. These data demonstrate the adverse effects of high doses of BPA on processes critical for embryo implantation: embryo transport, preimplantation embryo development, and establishment of uterine receptivity.
KW - Bisphenol A
KW - Embryo implantation
KW - Embryo transport
KW - Preimplantation embryo development
KW - Progesterone receptor
KW - Uterine receptivity
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U2 - 10.1016/j.reprotox.2011.08.010
DO - 10.1016/j.reprotox.2011.08.010
M3 - Article
C2 - 21907787
AN - SCOPUS:82155172913
SN - 0890-6238
VL - 32
SP - 434
EP - 441
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 4
ER -