Preliminarily development of a moisture-activated bioresorbable polymeric platform for drug delivery

Renê O. Do Couto, Sven D. Sommerfeld, Koustubh Dube, Osvaldo De Freitas, Joachim Kohn

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Bioresorbable polymeric films were prepared by solvent casting using a tyrosine-derived polycarbonate and metronidazole (MDZ) as the model drug at 2.5%, 5% and 10% (w/w). Drug loading did not affect the water uptake, drug release, polymer degradation or erosion profiles. All devices released approximately 85% (w/w) of the drug within a 1.5 h period. This may be attributed to the rapid water uptake of the polymer. An increase in the water uptake correlated with a linear rate increase of the polymer degradation (0.968 ? R2 ? 0.999). Moreover, MDZ presented a remarkable plasticizing effect for the polymer and drug loading exerted a significant impact on the mechanical properties of the obtained films. The results obtained can be used to further the development of novel biocompatible and biodegradable polymeric platforms for the delivery of metronidazole and other drugs in a broad range of pharmaceutical applications.

Original languageEnglish (US)
Pages (from-to)902-909
Number of pages8
JournalQuimica Nova
Volume38
Issue number7
DOIs
StatePublished - Aug 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Keywords

  • Drug delivery platform
  • Hydrolytically degradable polymer
  • Metronidazole
  • Plasticizer
  • Tyrosine-derived polymers

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