Premature maternal separation and lymphocyte function

Sigurd H. Ackerman, Steven E. Keller, Steven J. Schleifer, Richard D. Shindledecker, Maria Camerino, Myron A. Hofer, Herbert Weiner, Marvin Stein

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Premature separation of rat pups from their mothers, on postnatal Day 15, produced a decreased response of peripheral blood lymphocytes to phytohemagglutnin (PHA) at 40 days of age. A significant lymphopenia was also found in the early weaned animals at 40 days of age although this was accounted for statistically by their lower body weight. These consequences of early maternal separation may have been mediated through the effects of early separation on nutritional state, hypothalamic function, or maturation of the immune system.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalBrain Behavior and Immunity
Issue number2
StatePublished - Jun 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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