Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method

Wojciech L. Suchanek; Kullaiah Byrappa; Pavel Shuk; Richard E. Riman; Victor F. Janas; Kevor S. Tenhuisen

doi:10.1016/j.biomaterials.2003.12.008

Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method

Wojciech L. Suchanek, Kullaiah Byrappa, Pavel Shuk, Richard E. Riman, Victor F. Janas, Kevor S. Tenhuisen

School of Engineering, Materials Science & Engineering

Research output: Contribution to journal › Article › peer-review

325 Scopus citations

Abstract

Magnesium-substituted hydroxyapatite (Mg-HAp) powders with different crystallinity levels were prepared at room temperature via a heterogeneous reaction between Mg(OH)₂/Ca(OH)₂ powders and an (NH ₄)₂HPO₄ solution using the mechanochemical- hydrothermal route. The as-prepared products contained unreacted Mg(OH) ₂ and therefore had to undergo purification in ammonium citrate aqueous solutions at room temperature. X-ray diffraction, infrared spectroscopy, thermogravimetric and chemical analyses were performed and it was determined that the purified powders were phase-pure Mg-HAp containing 0.24-28.4wt% of Mg. The concentration of Mg was slightly lower near the surface than in the bulk of the HAp crystals as indicated by X-ray photoelectron spectroscopy. Dynamic light scattering revealed that the median particle size of the room temperature Mg-HAp powders was in the range of 102nm-1.2μm with a specific surface area between 91 and 269m²/g. Scanning electron microscopy confirmed that the Mg-HAp powders consisted of submicron agglomerates of nanosized crystals, less than ≈20nm.

Original language	English (US)
Pages (from-to)	4647-4657
Number of pages	11
Journal	Biomaterials
Volume	25
Issue number	19
DOIs	https://doi.org/10.1016/j.biomaterials.2003.12.008
State	Published - Aug 2004

All Science Journal Classification (ASJC) codes

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

Keywords

Crystallinity
Hydrothermal synthesis
Hydroxyapatite
Magnesium
Mechanochemical synthesis
Nanoparticle

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10.1016/j.biomaterials.2003.12.008

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title = "Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method",

abstract = "Magnesium-substituted hydroxyapatite (Mg-HAp) powders with different crystallinity levels were prepared at room temperature via a heterogeneous reaction between Mg(OH)2/Ca(OH)2 powders and an (NH 4)2HPO4 solution using the mechanochemical- hydrothermal route. The as-prepared products contained unreacted Mg(OH) 2 and therefore had to undergo purification in ammonium citrate aqueous solutions at room temperature. X-ray diffraction, infrared spectroscopy, thermogravimetric and chemical analyses were performed and it was determined that the purified powders were phase-pure Mg-HAp containing 0.24-28.4wt% of Mg. The concentration of Mg was slightly lower near the surface than in the bulk of the HAp crystals as indicated by X-ray photoelectron spectroscopy. Dynamic light scattering revealed that the median particle size of the room temperature Mg-HAp powders was in the range of 102nm-1.2μm with a specific surface area between 91 and 269m2/g. Scanning electron microscopy confirmed that the Mg-HAp powders consisted of submicron agglomerates of nanosized crystals, less than ≈20nm.",

keywords = "Crystallinity, Hydrothermal synthesis, Hydroxyapatite, Magnesium, Mechanochemical synthesis, Nanoparticle",

author = "Suchanek, {Wojciech L.} and Kullaiah Byrappa and Pavel Shuk and Riman, {Richard E.} and Janas, {Victor F.} and Tenhuisen, {Kevor S.}",

note = "Funding Information: This research was supported by the Johnson & Johnson Center for Biomaterials and Advanced Technologies, the Center for Biomedical Devices at Rutgers University, and the National Institute of Health. The authors are greatly indebted to James Kim for experimental assistance, Eric Gulliver and Mohit Jain for obtaining the FESEM images, and to Kelly Brown for the XPS analysis.",

year = "2004",

month = aug,

doi = "10.1016/j.biomaterials.2003.12.008",

language = "English (US)",

volume = "25",

pages = "4647--4657",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier Ltd",

number = "19",

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TY - JOUR

T1 - Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method

AU - Suchanek, Wojciech L.

AU - Byrappa, Kullaiah

AU - Shuk, Pavel

AU - Riman, Richard E.

AU - Janas, Victor F.

AU - Tenhuisen, Kevor S.

N1 - Funding Information: This research was supported by the Johnson & Johnson Center for Biomaterials and Advanced Technologies, the Center for Biomedical Devices at Rutgers University, and the National Institute of Health. The authors are greatly indebted to James Kim for experimental assistance, Eric Gulliver and Mohit Jain for obtaining the FESEM images, and to Kelly Brown for the XPS analysis.

PY - 2004/8

Y1 - 2004/8

N2 - Magnesium-substituted hydroxyapatite (Mg-HAp) powders with different crystallinity levels were prepared at room temperature via a heterogeneous reaction between Mg(OH)2/Ca(OH)2 powders and an (NH 4)2HPO4 solution using the mechanochemical- hydrothermal route. The as-prepared products contained unreacted Mg(OH) 2 and therefore had to undergo purification in ammonium citrate aqueous solutions at room temperature. X-ray diffraction, infrared spectroscopy, thermogravimetric and chemical analyses were performed and it was determined that the purified powders were phase-pure Mg-HAp containing 0.24-28.4wt% of Mg. The concentration of Mg was slightly lower near the surface than in the bulk of the HAp crystals as indicated by X-ray photoelectron spectroscopy. Dynamic light scattering revealed that the median particle size of the room temperature Mg-HAp powders was in the range of 102nm-1.2μm with a specific surface area between 91 and 269m2/g. Scanning electron microscopy confirmed that the Mg-HAp powders consisted of submicron agglomerates of nanosized crystals, less than ≈20nm.

AB - Magnesium-substituted hydroxyapatite (Mg-HAp) powders with different crystallinity levels were prepared at room temperature via a heterogeneous reaction between Mg(OH)2/Ca(OH)2 powders and an (NH 4)2HPO4 solution using the mechanochemical- hydrothermal route. The as-prepared products contained unreacted Mg(OH) 2 and therefore had to undergo purification in ammonium citrate aqueous solutions at room temperature. X-ray diffraction, infrared spectroscopy, thermogravimetric and chemical analyses were performed and it was determined that the purified powders were phase-pure Mg-HAp containing 0.24-28.4wt% of Mg. The concentration of Mg was slightly lower near the surface than in the bulk of the HAp crystals as indicated by X-ray photoelectron spectroscopy. Dynamic light scattering revealed that the median particle size of the room temperature Mg-HAp powders was in the range of 102nm-1.2μm with a specific surface area between 91 and 269m2/g. Scanning electron microscopy confirmed that the Mg-HAp powders consisted of submicron agglomerates of nanosized crystals, less than ≈20nm.

KW - Crystallinity

KW - Hydrothermal synthesis

KW - Hydroxyapatite

KW - Magnesium

KW - Mechanochemical synthesis

KW - Nanoparticle

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JO - Biomaterials

JF - Biomaterials

IS - 19

ER -

Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method

Abstract

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