Pressure pulse transmission into vascular beds

Arnold G. Salotto, Lawrence F. Muscarella, Julius Melbin, John Li, Abraham Noordergraaf

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.

Original languageEnglish (US)
Pages (from-to)152-163
Number of pages12
JournalMicrovascular Research
Volume32
Issue number2
DOIs
StatePublished - Jan 1 1986

Fingerprint

Blood Vessels
Pulse
Blood Pressure
Wave transmission
Pulse Wave Analysis
Microvessels
Vasoconstriction
Arteries

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Salotto, A. G., Muscarella, L. F., Melbin, J., Li, J., & Noordergraaf, A. (1986). Pressure pulse transmission into vascular beds. Microvascular Research, 32(2), 152-163. https://doi.org/10.1016/0026-2862(86)90051-8
Salotto, Arnold G. ; Muscarella, Lawrence F. ; Melbin, Julius ; Li, John ; Noordergraaf, Abraham. / Pressure pulse transmission into vascular beds. In: Microvascular Research. 1986 ; Vol. 32, No. 2. pp. 152-163.
@article{919e15e4b3764fdda308080f8418720a,
title = "Pressure pulse transmission into vascular beds",
abstract = "Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.",
author = "Salotto, {Arnold G.} and Muscarella, {Lawrence F.} and Julius Melbin and John Li and Abraham Noordergraaf",
year = "1986",
month = "1",
day = "1",
doi = "10.1016/0026-2862(86)90051-8",
language = "English (US)",
volume = "32",
pages = "152--163",
journal = "Microvascular Research",
issn = "0026-2862",
publisher = "Academic Press Inc.",
number = "2",

}

Salotto, AG, Muscarella, LF, Melbin, J, Li, J & Noordergraaf, A 1986, 'Pressure pulse transmission into vascular beds', Microvascular Research, vol. 32, no. 2, pp. 152-163. https://doi.org/10.1016/0026-2862(86)90051-8

Pressure pulse transmission into vascular beds. / Salotto, Arnold G.; Muscarella, Lawrence F.; Melbin, Julius; Li, John; Noordergraaf, Abraham.

In: Microvascular Research, Vol. 32, No. 2, 01.01.1986, p. 152-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pressure pulse transmission into vascular beds

AU - Salotto, Arnold G.

AU - Muscarella, Lawrence F.

AU - Melbin, Julius

AU - Li, John

AU - Noordergraaf, Abraham

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.

AB - Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.

UR - http://www.scopus.com/inward/record.url?scp=0022477601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022477601&partnerID=8YFLogxK

U2 - 10.1016/0026-2862(86)90051-8

DO - 10.1016/0026-2862(86)90051-8

M3 - Article

C2 - 3762424

AN - SCOPUS:0022477601

VL - 32

SP - 152

EP - 163

JO - Microvascular Research

JF - Microvascular Research

SN - 0026-2862

IS - 2

ER -

Salotto AG, Muscarella LF, Melbin J, Li J, Noordergraaf A. Pressure pulse transmission into vascular beds. Microvascular Research. 1986 Jan 1;32(2):152-163. https://doi.org/10.1016/0026-2862(86)90051-8