Abstract
Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-163 |
| Number of pages | 12 |
| Journal | Microvascular Research |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1986 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Cardiology and Cardiovascular Medicine
- Cell Biology
Cite this
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Pressure pulse transmission into vascular beds. / Salotto, Arnold G.; Muscarella, Lawrence F.; Melbin, Julius; Li, John; Noordergraaf, Abraham.
In: Microvascular Research, Vol. 32, No. 2, 01.01.1986, p. 152-163.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pressure pulse transmission into vascular beds
AU - Salotto, Arnold G.
AU - Muscarella, Lawrence F.
AU - Melbin, Julius
AU - Li, John
AU - Noordergraaf, Abraham
PY - 1986/1/1
Y1 - 1986/1/1
N2 - Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.
AB - Observations at the microcirculatory level have revealed that (a) the pressure pulse reaches the smallest vessel, and (b) the pulse wave velocity alters from a value in the order of meters/second in large arteries to a value in the order of centimeters/second in the microvessels. We investigate, herein, whether these experimental findings are consonant with linear pulse wave transmission theory in a branching system of vessels. Our computations, utilizing available data, show that this is indeed the case. For low frequency (1 Hz), cumulative attenuation is such that about one-third of the pulse, originating at the heart, reaches the capillary. A 10-Hz pulse, however, is virtually completely attenuated by the time the cpaillary is reached. Transmission time for a pulse, from heart to capillary, is also frequency dependent, with higher frequencies propagating more rapidly. Vasoconstriction, at the arteriolar level in the absence of reflection, can also strongly attenuate the pulse remnant at that site.
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U2 - 10.1016/0026-2862(86)90051-8
DO - 10.1016/0026-2862(86)90051-8
M3 - Article
C2 - 3762424
AN - SCOPUS:0022477601
VL - 32
SP - 152
EP - 163
JO - Microvascular Research
JF - Microvascular Research
SN - 0026-2862
IS - 2
ER -