Prevention of Breast Cancer by Natural Phytochemicals: Focusing on Molecular Targets and Combinational Strategy

Yi Shiou Chiou, Shiming Li, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Starting from the 21st century, breast cancer can be classified as the most common invasive malignancy in women. Among the preventive or therapeutic strategies of breast cancer, combination therapy is the most promising approach. This mode of treatment of breast cancer concurrently maximizes efficacy, overcomes multidrug resistance, and minimizes harmful side effects caused by radiotherapy and chemotherapy alone. The risk of cancer can be reduced by supplementing diets with naturally occurring products known as phytochemicals. These phytochemicals have well-defined roles in the management of every stage of breast carcinogenesis. In this review, the collective data of dietary phytochemicals used to sensitize breast cancer cells to therapeutic approaches are reported and their specific molecular targets through synergistic, additive, and potentiation effects are highlighted. The concept of combining natural agents with medicines to augment therapeutic responses creates an optimal modality, which may facilitate clinical applications of combination regimens in the future.

Original languageEnglish (US)
Article number1800392
JournalMolecular Nutrition and Food Research
Issue number23
StatePublished - Dec 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science


  • breast carcinogenesis
  • clinical applications
  • combination regimens
  • dietary phytochemicals


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