Prevention of Obesity and Type 2 Diabetes with Aged Citrus Peel (Chenpi) Extract

Jingjing Guo, Hanlin Tao, Yong Cao, Chi Tang Ho, Shengkang Jin, Qingrong Huang

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91 Scopus citations


Chenpi is the dry peel of the plant Citrus reticulata Blanco after an aging processing. It has been used as an antidigestive and anti-inflammatory traditional medicine, as well as culinary seasoning and dietary supplement, in China. However, its efficacy and underlying scientific mechanism have not been sufficiently investigated. Chenpi is uniquely enriched with a high content of 5-demethylated polymethoxyflavones (5-OH PMFs). The effect of chenpi extract on improving metabolic features was examined using high-fat diet (HFD)-induced obesity/diabetes mouse model. Oral administration of 0.25 and 0.5% chenpi extract in food over 15 weeks markedly prevented HFD-induced obesity, hepatic steatosis, and diabetic symptoms. The beneficial effect is associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) activation in adipose tissue. Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.

Original languageEnglish (US)
Pages (from-to)2053-2061
Number of pages9
JournalJournal of agricultural and food chemistry
Issue number10
StatePublished - Mar 16 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


  • 5-demethylated polymethoxyflavones
  • chenpi
  • diabetes
  • insulin resistance
  • obesity


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