Principles of translational control

John W.B. Hershey, Nahum Sonenberg, Michael B. Mathews

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Protein synthesis involves a complex machinery comprising numerous proteins and RNAs joined by noncovalent interactions. Its function is to link long chains of amino acids into proteins with precise sequences as encoded by the genome. Regulation of protein synthesis, called translational control, occurs both at a global level and at specific messenger RNAs (mRNAs). To understand how translation is regulated, knowledge of the molecular structures and kinetic interactions of its components is needed. This review focuses on the targets of translational control and the mechanisms employed.

Original languageEnglish (US)
Article numbera032607
JournalCold Spring Harbor Perspectives in Biology
Issue number9
StatePublished - Sep 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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