Prion protein regulates glutamate-dependent lactate transport of astrocytes

Ralf Kleene, Gabriele Loers, Julia Langer, Yveline Frobert, Friedrich Buck, Melitta Camartin

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Prion-related protein (PrP) is a neural cell adhesion molecule involved in neurite outgrowth, neuronal survival, and synaptic function. In search of novel binding partners for PrP, we identified the α2/β2-Na +/K+-ATPase and showed that this astroglial ATPase interacts directly with the immunoglobulin superfamily adhesion molecule basigin. In cultured astrocytes, PrP is involved in regulating lactate transport via the astroglial monocarboxylate transporter 1 (MCT1) and in conjunction with α2/β2-ATPase and basigin. Lactate transport via MCT1 is glutamate dependent and regulated by glutamate receptor 2 (GluR2)-containing AMPA receptors with which PrP interacts. The functional interplay between PrP, GluR2, α2/β2-ATPase, basigin, and MCT1 in regulating lactate transport of astrocytes may be functional in the metabolic cross talk between astrocytes and neurons, most likely under stress.

Original languageEnglish (US)
Pages (from-to)12331-12340
Number of pages10
JournalJournal of Neuroscience
Volume27
Issue number45
DOIs
StatePublished - Nov 7 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • AMPA receptor
  • Astrocytes
  • Basigin
  • Lactate transport
  • Na/K-ATPase
  • Prion protein

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