Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials

Kelly A. Tiderencel, Deborah A. Hutcheon, Jane Ziegler

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is increased interest in probiotic supplementation for improving glycaemic control. This review evaluates nine randomized controlled trials that tested the effects of probiotics on glycaemic outcomes including fasting plasma glucose, fasting plasma insulin, haemoglobin A1c, and homeostatic model assessment of insulin resistance among adults with T2DM. Based on the evidence reviewed, multistrain probiotics that contain seven million to 100 billion colony forming units of Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus, and/or Bifidobacterium lactis administered for 6 to 12 weeks may be efficacious for improving glycaemic control in adults with T2DM. Further research is needed to understand the role of the gut microbiota and the probiotic dose, medium, and duration of exposure that is most effective for disease management.

Original languageEnglish (US)
Article numbere3213
JournalDiabetes/Metabolism Research and Reviews
Issue number1
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


  • diabetes mellitus
  • gastrointestinal microbiome
  • insulin resistance
  • metabolism
  • probiotics


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