Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models

Zilong Wang, M. Sebastian Escotet-Espinoza, Marianthi Ierapetritou

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Continuous manufacturing has attracted increasing research attention in the pharmaceutical industry within the last decade. Based on the extensive experimental studies, numerous modeling and computational approaches have been developed to capture the process information and make predictions. Moreover, flowsheet models have been built to simulate the dynamic behaviors of a plant-wide manufacturing process with respect to different process input factors. However, there still lacks a systematic way to make the best use of flowsheet models in pharmaceutical processes. In this work, we propose a framework of process analysis and optimization for the continuous pharmaceutical manufacturing process where flowsheet models are available. Specifically, sensitivity analysis is conducted to identify the input factors that are most influential on the output; feasibility analysis is then implemented to characterize the design space in the high-dimensional space. Finally, process optimization is performed to find the optimal operation conditions that result in the minimum cost.

Original languageEnglish (US)
Pages (from-to)77-91
Number of pages15
JournalComputers and Chemical Engineering
Volume107
DOIs
StatePublished - Dec 5 2017

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

Keywords

  • Continuous pharmaceutical manufacturing
  • Design space
  • Flowsheet modeling
  • Optimization
  • Sensitivity analysis

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