Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: Association with enterotoxin A

B. D. McCollister, B. N. Kreiswirth, R. P. Novick, P. M. Schlievert

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Staphylococcus aureus D4508, obtained from a patient with nonmenstrual toxic shock syndrome (TSS) produced enterotoxin A while not making other known enterotoxins or TSS toxin 1. Concentrated culture fluids of the organism, administered subcutaneously in miniosmotic pumps, induced TSS-like symptoms (four of six animals succumbed). Identical culture fluids pretreated with anti-enterotoxin A serum failed to induce symptoms except for fever (none of six animals succumbed). Purified staphylococcal enterotoxin A also had the ability to induce TSS-like symptoms. These data suggest that enterotoxin A is the major TSS-associated toxin made by strain D4508.

Original languageEnglish (US)
Pages (from-to)2067-2070
Number of pages4
JournalInfection and immunity
Volume58
Issue number7
StatePublished - Jan 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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