Prognostic significance of receptors for the third component of complement and heavy chain phenotype in diffuse B-cell lymphomas

E. J. Gold, R. H. Mertelsmann, D. A. Filippa, T. H. Szatrowski, B. Koziner, B. Clarkson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

As part of a larger study to determine the prognostic significance of cell marker phenotype in diffuse lymphomas, 51 patients with monoclonal B-cell lymphoma were further characterized by receptors for C3 (EAC rosettes) as well as heavy and light chain phenotypes. Patients with greater than 10% EAC rosette-forming cells were found to have a statistically significant longer survival than those with less than 10% EAC rosettes (p = 0.005). A similar trend in survival duration was found for patients whose cells expressed mu heavy chain on their surfaces when compared to those with gamma heavy chain on their cell surfaces (p = 0.05). No correlation was observed between these prognostic groups and any of the three most frequently used histologic classifications (i.e., Rappaport, Lukes, Kiel).

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalUnknown Journal
Volume62
Issue number1
DOIs
StatePublished - 1983

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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