Progress in the Design of DNA Sequence-Specific Lexitropsins

Wynn L. Walker, Mary L. Kopka, David S. Goodsell

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-hinding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalBiopolymers - Biospectroscopy Section
Volume44
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

Keywords

  • DNA
  • Lexitropsins
  • Minor groove
  • Rational drug design
  • Sequence-specific polyamides

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