Progress in the Design of DNA Sequence-Specific Lexitropsins

Wynn L. Walker; Mary L. Kopka; David S. Goodsell

doi:10.1002/(SICI)1097-0282(1997)44:4<323::AID-BIP2>3.0.CO;2-0

Progress in the Design of DNA Sequence-Specific Lexitropsins

Wynn L. Walker, Mary L. Kopka, David S. Goodsell

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-hinding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.

Original language	English (US)
Pages (from-to)	323-334
Number of pages	12
Journal	Biopolymers - Biospectroscopy Section
Volume	44
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1097-0282(1997)44:4<323::AID-BIP2>3.0.CO;2-0
State	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

Keywords

DNA
Lexitropsins
Minor groove
Rational drug design
Sequence-specific polyamides

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10.1002/(SICI)1097-0282(1997)44:4<323::AID-BIP2>3.0.CO;2-0

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AU - Kopka, Mary L.

AU - Goodsell, David S.

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Y1 - 1997

N2 - Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-hinding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.

AB - Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-hinding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.

KW - DNA

KW - Lexitropsins

KW - Minor groove

KW - Rational drug design

KW - Sequence-specific polyamides

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ER -

Progress in the Design of DNA Sequence-Specific Lexitropsins

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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