@article{9d656bc84e7a4e34b504f86837e2393a,
title = "Promoter variation and gene expression of mcr-1-harboring plasmids in clinical isolates of Escherichia coli and klebsiella pneumoniae from a Chinese Hospital",
abstract = "Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.",
keywords = "Colistin, Gene expression, Genomics, Plasmids, Promoter",
author = "Bin Huang and Yuting He and Xingyan Ma and Renxin Cai and Jianming Zeng and Yang Lu and Weizheng Zhang and Kai Lan and E. Sunmei and Tang, {Yi Wei} and Kreiswirth, {Barry N.} and Cha Chen and Liang Chen",
note = "Funding Information: The study was supported in part by the National Natural Science Foundation of China (grants 81572058, 81672081, and 81772249), the Guangdong Natural Science Foundation (grant 2014A030313143), and the State Education Ministry Scientific Research Foundation for the Returned Overseas Chinese Scholars. This work was in part supported by grants from the National Institute of Allergy and Infectious Diseases (grant R01AI090155 to B.N.K. and grant R21AI117338 to L.C.). Publisher Copyright: {\textcopyright} 2018 American Society for Microbiology. All Rights Reserved.",
year = "2018",
month = may,
doi = "10.1128/AAC.00018-18",
language = "English (US)",
volume = "62",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",
}