Promotion of wound repair in mice by application of glucan

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The effects of topical application of a variety of substances (glucan, carrageenan, levan, inulin, dextran, starch and talcum powder) on the repair process of skin wounds in SWR mice were examined. Of the substances tested, only glucan showed any marked beneficial effects. Glucan-treated wounds showed a higher number of macrophages in the early, inflammatory stage of repair, with fewer polymorphonuclear neutrophilic leukocytes than did control wounds. Both re-epithelialization and the onset of fibroplasia commenced at an earlier stage in glucon-treated wounds than in control wounds. Five days following wounding, glucan-treated wounds were generally completely re-epithelialized, while control wounds were not. The organization of fibroblasts in glucan-treated wounds was more advanced at 5 and 7 days following injury, and the extent of fibroplasia was also greater. By 10 days following injury, glucan-treated wounds were completely re-epithialized, as were control wounds treated with medium alone, inulin, dextran, starch or talc. Carrageenan- and levan-treated wounds showed impaired re-epithelialization. Only occasional residual glucan-containing macrophages were present in the glucan-treated wounds at this stage. In glucan-treated wounds, no formation of granulomas was observed up to one month following wounding.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalRES Journal of the Reticuloendothelial Society
Issue number1
StatePublished - Jan 1 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology

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