Properties of a cytotoxic kidney antibody associated with human renal transplantation

N. Ende, E. V. Orsi, N. Z. Baturay, T. L. Britten

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A technique for demonstrating a complement-dependent cytotoxic response specific for human kidney cells was developed. Positive and negative sera from kidney-transplant recipients were subjected to several assay and adsorption procedures. The cytotoxic antibody reaction appeared to be specific against human kidney in tests with a variety of target cells. Manifestation of the typical cytotoxic effect depended on kidney explant target-cell surface changes following attachment, outgrowth, and dispersion of the first passage monolayer. A comparison of serum responses to lymphocytes and to kidney cells indicated that the cytotoxic response by human kidney cells is not related to the lymphocytotoxic antibodies associated with the HLA system.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1979

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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