Prophylactic antibiotics for cesarean section: Comparison of high- and low-risk patients for endomyometritis

Joseph J. Apuzzio, Christine Reyelt, Marco Pelosi, Purnendu Sen, Donald B. Louria

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The efficacy of ticarcillin in the prevention of post-cesarean section endomyometritis was studied in 259 women randomly given either the antibiotic or a placebo. The ticarcillin group received 6g intravenously immediately after delivery. Then 22 of those patients were also given a second 3-g dose 6 to 8 hours after delivery. Among the 139 patients who received ticarcillin, endomyometritis developed in 44 (32%), as it did in 66 of 120 patients (55%) in the placebo group. These differences are highly significant (P=.002). Of the 259 patients in the study, 238 could be classified as to risk for endomyometritis developing. Among the 124 high-risk patients, 52 received a placebo and endomyometritis developed in 71%. Only 26 of the 72 high-risk patients who received ticarcillin (36%) were so infected. Among the lowrisk patients, endomyometritis developed in 10 of 54 patients (18.5%) who received prophylaxis and in 24 of 60 patients who received placebo (40%). Ticarcillin appears to be effective in reducing the incidence of post-cesarean section endomyometritis in patients at high risk and in those at low risk. The number of pelvic examinations during labor was the most important single factor in the development of endomyometritis.

Original languageEnglish (US)
Pages (from-to)693-698
Number of pages6
JournalObstetrics and gynecology
Issue number6
StatePublished - Jun 1982

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Prophylactic antibiotics for cesarean section: Comparison of high- and low-risk patients for endomyometritis'. Together they form a unique fingerprint.

Cite this