Propofol-induced Neurotoxicity in the fetal animal brain and developments in modifying these effects-an updated review of propofol fetal exposure in laboratory animal studies

Ming Xiong, Li Zhang, Jing Li, Jean Eloy, Jiang Hong Ye, Alex Bekker

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegeneration in the developing brain and long-term neurobehavioral disturbances in both rodents and non-human primates. Despite the growing evidence of the potential neurotoxicity of different anesthetic agents in animal studies, there is no concrete evidence that humans may be similarly affected. However, given the growing evidence of the neurotoxic effects of anesthetics in laboratory studies, it is prudent to further investigate the mechanisms causing these effects and potential ways to mitigate them. Here, we review multiple studies that investigate the effects of in utero propofol exposure and the developmental agents that may modify these deleterious effects.

Original languageEnglish (US)
Article number11
JournalBrain Sciences
Volume6
Issue number2
DOIs
StatePublished - Mar 28 2016

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Apoptosis
  • In utero
  • Neurotoxicity
  • Propofol

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