Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City

Mahrukh Bamji, Donald M. Thea, Jeremy Weedon, Keith Krasinski, Pamela B. Matheson, Pauline Thomas, Genevieve Lambert, Elaine J. Abrams, Rick Steketee, Margaret Heagarty

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective. To determine the incidence of HIV-1-related clinical findings, mortality and predictors of death in a cohort of HIV-exposed infants followed from birth. Methods. Data were collected approximately bimonthly during the first and second year of life and used in Kaplan-Meier and Cox proportional hazards survival analyses to predict time to the development of symptoms and death. Results. One hundred sixteen infected and 396 uninfected infants were followed for a median of 26 months at 7 New York City hospitals from 1986 to 1995. Two or more nonspecific HIV-related symptoms, AIDS or death occurred in 83% of infected children by the first year. Fifty infected infants (43%) developed AIDS and 19 (38%) of these had Pneumocystis carinii pneumonia. Estimated median age at AIDS/death was 30 months and 64% of infected children remained alive and AIDS-free at 1 year. Estimated infant mortality among infected children was 160/1000 live births, and median survival after AIDS was 21 months; 55% of infected children survived >12 months after diagnosis of AIDS. P. carinii pneumonia was the most common cause of death. Although birth CD4 values did not predict AIDS or death, CD4 counts as early as 6 months of age were highly correlated with both. Thirteen (68%) of 19 infants who remained AIDS-free up to 3 to 6 months of age with CD4 count ≤1500 cells/μl subsequently developed AIDS vs. 18 (30%) of 61 with CD4 count >1500 (P = 0.0001). Conclusions. Most HIV-1- infected infants develop disease in the first year of life. AIDS or death can be predicted by a threshold CD4 count of 1500 cells/μl at 3 to 6 months of age.

Original languageEnglish (US)
Pages (from-to)891-898
Number of pages8
JournalPediatric Infectious Disease Journal
Volume15
Issue number10
DOIs
StatePublished - Oct 1 1996

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Keywords

  • Pediatric acquired immunodeficiency syndrome
  • morbidity
  • mortality
  • natural history
  • perinatal transmission
  • vertical transmission

Fingerprint Dive into the research topics of 'Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City'. Together they form a unique fingerprint.

  • Cite this

    Bamji, M., Thea, D. M., Weedon, J., Krasinski, K., Matheson, P. B., Thomas, P., Lambert, G., Abrams, E. J., Steketee, R., & Heagarty, M. (1996). Prospective study of human immunodeficiency virus 1-related disease among 512 infants born to infected women in New York City. Pediatric Infectious Disease Journal, 15(10), 891-898. https://doi.org/10.1097/00006454-199610000-00012