Prospects for antisense peptide nucleic acid (PNA) therapies for HIV

Virendra N. Pandey, Alok Upadhyay, Binay Chaubey

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation or transcription processes. This review discusses the present and future therapeutic potential of this class of compound as anti-HIV-1 drugs.

Original languageEnglish (US)
Pages (from-to)975-989
Number of pages15
JournalExpert Opinion on Biological Therapy
Volume9
Issue number8
DOIs
StatePublished - Aug 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Keywords

  • AIDS
  • HIV-1
  • Peptide nucleic acid
  • Virucidal

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