Prostacyclin (PGI2) Elicits Reflex Bradycardia in Dogs: Evidence for Vagal Mediation

Thomas H. Hintze, Eugene G. Martin, Edward J. Messina, Gabor Kaley

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Administration of the vasode-pressor prostaglandins, PGE1 and PGE2, and of nitroprusside, an agent whose direct vascular activity is similar to prostaglandins, resulted in a reduction in systemic arterial blood pressure accompanied by the expected reflex increase in heart rate. Injection of pros-tacyclin (PGI2) and the prostaglandin precursor, arachidonic acid, into the femoral vein, pulmonary artery, left atrium, and left ventricle of the dog elicited a fall in blood pressure and a concomitant reduction in heart rate in both open- and closed-chest anesthetized dogs. Bilateral vagal section eliminated the bradycardia thus establishing that the PGI2-induced change in heart rate is reflex in origin.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Oct 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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