Protection Against Acute MPTP‐Induced Dopamine Depletion in Mice by Adenosine A1 Agonist

Yuen‐Sum ‐S Lau, M Maral Mouradian

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Abstract: The effects of the adenosine A1 agonist N6‐cyclohexyladenosine (CHA) on MPTP‐induced dopamine (DA) depletion in the striatum of C57BL/6 mice were studied. Twenty hours after a single injection of MPTP (30 mg/kg, s.c.), the toxin caused 62% depletion of striatal DA. CHA (0.2–3 mg/kg, s.c.), when given together with MPTP, prevented the toxin‐induced DA depletion in a dose‐dependent manner. This protective action was apparently mediated by the A1 receptors, because this effect was selectively antagonized by pretreating the animals with the A1 antagonist 8‐cyclopentyl‐1,3‐dipropylxanthine (25 mg/kg, i.p.) but not with the A2 antagonist 1,3‐dipropyl‐7‐methylxanthine (25 mg/kg, i.p.). When CHA (3 mg/kg) was injected 5 h after MPTP administration, at which point striatal DA levels were already reduced significantly, a rapid and complete recovery of the striatal DA levels occurred. These neurochemical data suggest that the A1 agonist CHA is potentially useful as a neuroprotective agent against MPTP‐induced toxicity.

Original languageEnglish (US)
Pages (from-to)768-771
Number of pages4
JournalJournal of neurochemistry
Volume60
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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