Protein function in precision medicine: deep understanding with machine learning

Burkhard Rost, Predrag Radivojac, Yana Bromberg

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Precision medicine and personalized health efforts propose leveraging complex molecular, medical and family history, along with other types of personal data toward better life. We argue that this ambitious objective will require advanced and specialized machine learning solutions. Simply skimming some low-hanging results off the data wealth might have limited potential. Instead, we need to better understand all parts of the system to define medically relevant causes and effects: how do particular sequence variants affect particular proteins and pathways? How do these effects, in turn, cause the health or disease-related phenotype? Toward this end, deeper understanding will not simply diffuse from deeper machine learning, but from more explicit focus on understanding protein function, context-specific protein interaction networks, and impact of variation on both.

Original languageEnglish (US)
Pages (from-to)2327-2341
Number of pages15
JournalFEBS Letters
DOIs
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • computational prediction
  • molecular mechanism of disease
  • protein function
  • variant effect

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