Protein lysine acylation and cysteine succination by intermediates of energy metabolism

Hening Lin, Xiaoyang Su, Bin He

Research output: Contribution to journalReview articlepeer-review

160 Scopus citations


In the past few years, several new protein post-translational modifications that use intermediates in metabolism have been discovered. These include various acyl lysine modifications (formylation, propionylation, butyrylation, crotonylation, malonylation, succinylation, myristoylation) and cysteine succination. Here, we review the discovery and the current understanding of these modifications. Several of these modifications are regulated by the deacylases, sirtuins, which use nicotinamide adenine dinucleotide (NAD), an important metabolic small molecule. Interestingly, several of these modifications in turn regulate the activity of metabolic enzymes. These new modifications reveal interesting connections between metabolism and protein post-translational modifications and raise many questions for future investigations.

Original languageEnglish (US)
Pages (from-to)947-960
Number of pages14
JournalACS chemical biology
Issue number6
StatePublished - Jun 15 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine


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