Protein nanostructures formed via direct-write dip-pen nanolithography

Ki Bum Lee, Jung Hyurk Lim, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

332 Scopus citations


We report a tip modification strategy coupled with dip-pen nanolithography for depositing proteins on a surface. This methodology offers patterning capabilities on the scale of 45 nm to many micrometers length. The biorecognition properties of nanofeatures composed of immunoglobulin-gamma (IgG) were confirmed by reacting the array with gold nanoparticles coated with anti-IgG. Furthermore, a two component nanoarray was fabricated in direct-write fashion by DPN, and the biorecognition properties of this structure were investigated by AFM without biodiagnostic labels.

Original languageEnglish (US)
Pages (from-to)5588-5589
Number of pages2
JournalJournal of the American Chemical Society
Issue number19
StatePublished - May 14 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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