Protons at the gate: DEG/ENaC ion channels help us feel and remember

Laura Bianchi; Monica Driscoll

doi:10.1016/S0896-6273(02)00687-6

Protons at the gate: DEG/ENaC ion channels help us feel and remember

Laura Bianchi, Monica Driscoll

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

The DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning.

Original language	English (US)
Pages (from-to)	337-340
Number of pages	4
Journal	Neuron
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/S0896-6273(02)00687-6
State	Published - Apr 25 2002

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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AB - The DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning.

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Protons at the gate: DEG/ENaC ion channels help us feel and remember

Abstract

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