TY - JOUR
T1 - Protons at the gate
T2 - DEG/ENaC ion channels help us feel and remember
AU - Bianchi, Laura
AU - Driscoll, Monica
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/4/25
Y1 - 2002/4/25
N2 - The DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning.
AB - The DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning.
UR - http://www.scopus.com/inward/record.url?scp=0037171860&partnerID=8YFLogxK
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U2 - 10.1016/S0896-6273(02)00687-6
DO - 10.1016/S0896-6273(02)00687-6
M3 - Review article
C2 - 11988165
AN - SCOPUS:0037171860
VL - 34
SP - 337
EP - 340
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 3
ER -