Pseudogymnoascus destructans: Causative agent of white-nose syndrome in bats is inhibited by safe volatile organic compounds

Sally Padhi, Itamar Dias, Victoria L. Korn, Joan Bennett

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

White-nose syndrome (WNS) is caused by Pseudogymnoascus destructans, a psychrophilic fungus that infects hibernating bats and has caused a serious decline in some species. Natural aroma compounds have been used to control growth of fungal food storage pathogens, so we hypothesized that a similar strategy could work for control of P. destructans. The effectiveness of exposure to low concentrations of the vapor phase of four of these compounds was tested on mycelial plugs and conidiospores at temperatures of 5, 10 and 15C. Here we report the efficacy of vapor phase mushroom alcohol (1-octen-3-ol) for inhibiting mycelial and conidiospore growth of P. destructans at 0.4 and 0.8 µmol/mL and demonstrate that the R enantiomer of this compound is more effective than the S enantiomer, supporting the finding that biological systems can be sensitive to stereochemistry. Further, we report that vapor phase leaf aldehyde (trans-2-hexenal), a common aroma compound associated with cut grass odors and also the major volatile compound in extra virgin olive oil, is more effective than mushroom alcohol. At 0.05 µmol/mL, trans-2-hexenal is fungicidal to both conidiospores and mycelia of P. destructans.

Original languageEnglish (US)
Article number48
JournalJournal of Fungi
Volume4
Issue number2
DOIs
StatePublished - Jun 1 2018

Fingerprint

volatile organic compounds
mushroom
bat
volatile organic compound
Chiroptera
alcohol
food storage
vapors
enantiomers
aldehyde
odor compounds
mushrooms
odor
psychrophilic fungi
alcohols
pathogen
fungus
grass
octenol
extra-virgin olive oil

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science

Keywords

  • (R)-(−)-1-octen-3-ol (R form)
  • (S)-(+)-1-octen-3-ol (S form)
  • 1-octen-3-ol (mushroom alcohol)
  • Bats
  • Pseudogymnoascus destructans
  • Trans-2-hexenal (leaf aldehyde)
  • Volatile organic compounds (VOCs)
  • White-nose syndrome (WNS)

Cite this

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title = "Pseudogymnoascus destructans: Causative agent of white-nose syndrome in bats is inhibited by safe volatile organic compounds",
abstract = "White-nose syndrome (WNS) is caused by Pseudogymnoascus destructans, a psychrophilic fungus that infects hibernating bats and has caused a serious decline in some species. Natural aroma compounds have been used to control growth of fungal food storage pathogens, so we hypothesized that a similar strategy could work for control of P. destructans. The effectiveness of exposure to low concentrations of the vapor phase of four of these compounds was tested on mycelial plugs and conidiospores at temperatures of 5, 10 and 15◦C. Here we report the efficacy of vapor phase mushroom alcohol (1-octen-3-ol) for inhibiting mycelial and conidiospore growth of P. destructans at 0.4 and 0.8 µmol/mL and demonstrate that the R enantiomer of this compound is more effective than the S enantiomer, supporting the finding that biological systems can be sensitive to stereochemistry. Further, we report that vapor phase leaf aldehyde (trans-2-hexenal), a common aroma compound associated with cut grass odors and also the major volatile compound in extra virgin olive oil, is more effective than mushroom alcohol. At 0.05 µmol/mL, trans-2-hexenal is fungicidal to both conidiospores and mycelia of P. destructans.",
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author = "Sally Padhi and Itamar Dias and Korn, {Victoria L.} and Joan Bennett",
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Pseudogymnoascus destructans : Causative agent of white-nose syndrome in bats is inhibited by safe volatile organic compounds. / Padhi, Sally; Dias, Itamar; Korn, Victoria L.; Bennett, Joan.

In: Journal of Fungi, Vol. 4, No. 2, 48, 01.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pseudogymnoascus destructans

T2 - Causative agent of white-nose syndrome in bats is inhibited by safe volatile organic compounds

AU - Padhi, Sally

AU - Dias, Itamar

AU - Korn, Victoria L.

AU - Bennett, Joan

PY - 2018/6/1

Y1 - 2018/6/1

N2 - White-nose syndrome (WNS) is caused by Pseudogymnoascus destructans, a psychrophilic fungus that infects hibernating bats and has caused a serious decline in some species. Natural aroma compounds have been used to control growth of fungal food storage pathogens, so we hypothesized that a similar strategy could work for control of P. destructans. The effectiveness of exposure to low concentrations of the vapor phase of four of these compounds was tested on mycelial plugs and conidiospores at temperatures of 5, 10 and 15◦C. Here we report the efficacy of vapor phase mushroom alcohol (1-octen-3-ol) for inhibiting mycelial and conidiospore growth of P. destructans at 0.4 and 0.8 µmol/mL and demonstrate that the R enantiomer of this compound is more effective than the S enantiomer, supporting the finding that biological systems can be sensitive to stereochemistry. Further, we report that vapor phase leaf aldehyde (trans-2-hexenal), a common aroma compound associated with cut grass odors and also the major volatile compound in extra virgin olive oil, is more effective than mushroom alcohol. At 0.05 µmol/mL, trans-2-hexenal is fungicidal to both conidiospores and mycelia of P. destructans.

AB - White-nose syndrome (WNS) is caused by Pseudogymnoascus destructans, a psychrophilic fungus that infects hibernating bats and has caused a serious decline in some species. Natural aroma compounds have been used to control growth of fungal food storage pathogens, so we hypothesized that a similar strategy could work for control of P. destructans. The effectiveness of exposure to low concentrations of the vapor phase of four of these compounds was tested on mycelial plugs and conidiospores at temperatures of 5, 10 and 15◦C. Here we report the efficacy of vapor phase mushroom alcohol (1-octen-3-ol) for inhibiting mycelial and conidiospore growth of P. destructans at 0.4 and 0.8 µmol/mL and demonstrate that the R enantiomer of this compound is more effective than the S enantiomer, supporting the finding that biological systems can be sensitive to stereochemistry. Further, we report that vapor phase leaf aldehyde (trans-2-hexenal), a common aroma compound associated with cut grass odors and also the major volatile compound in extra virgin olive oil, is more effective than mushroom alcohol. At 0.05 µmol/mL, trans-2-hexenal is fungicidal to both conidiospores and mycelia of P. destructans.

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KW - 1-octen-3-ol (mushroom alcohol)

KW - Bats

KW - Pseudogymnoascus destructans

KW - Trans-2-hexenal (leaf aldehyde)

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